Ukuthi izibulala-zinambuzane zibangela izicubu manje kubonakala sekutholakele. Hhayi nje i- i-glyphosate ngazo zonke izinhlobo zayo ihlotshaniswa nokuqala komdlavuza, noma uzimisele izibulala-zinambuzane ezisengozini yokwanda komdlavuza wezingane wesistimu yezinzwa emaphakathi, manje sekucaca ukuthi ngisho nokuchayeka ekudleni kwemithi ethile yokubulala izinambuzane kungadala umdlavuza webele we-postmenopausal.
Yilokhu okuvela kokukodwa studio I-French eholwa yiqembu labacwaningi abavela ku-CNAM, INSERM nase-INRAE futhi yashicilelwa kuI-International Journal ye-Epidemiology, kuhlolwa ukuhlangana phakathi kokuchayeka ekudleni emithini yokubulala izinambuzane kanye nengozi yokuba nomdlavuza webele kubantu besifazane abangemva kokuya esikhathini abasenkampanini yephrojekthi yeNutriNet-Santé.
Ucwaningo belubandakanya abesifazane abangu-13.149 abaya emuva kokuya esikhathini, okubandakanya namacala angu-169 omdlavuza. Abaphenyi balinganisa ukuvezwa kwezinto ezingama-25 ezisebenzayo ekwakhiweni kwezibulala-zinambuzane ezigunyaziwe ku Europa, kuqala ngalezo ezisetshenziselwa ukulima ngokwemvelo.
Empeleni, ngokusolakala kocwaningo, kusolwa ukuthi ezinye izibulala-zinambuzane ezisetshenziswa eYurophu zinemiphumela eyingozi empilweni yomuntu: zidala ukuphazamiseka kwamahomoni futhi zinezinto ezibanga umdlavuza. Ukuxhumana phakathi kokuchayeka emithini yokubulala izinambuzane ngokudla nangomdlavuza webele kubantu abaningi kusacutshungulwa kabi. Abaphenyi base bevele bekhombisile ukuthi abathengi bokudla okulinywe emzimbeni weqembu leNutriNet-Santé babe nengozi encane yomdlavuza we-postmenopausal. Leli qembu elifanayo liqhubekile nomsebenzi walo, kulokhu ligxile ekuvezeni ama-cocktails ahlukahlukene wezibulala-zinambuzane kulesi sigaba sabantu.
Ucwaningo
Ucwaningo olusha lweminyaka emine luqale ngonyaka we-2014. Ababambe iqhaza bagcwalise uhlu lwemibuzo lokuhlola ukusetshenziswa kokudla okuphilayo nokujwayelekile. Bangu-13.149 169 abantu besifazane abangemva kokuya esikhathini abaye bafakwa kulolu cwaningo kanti kwabikwa ukuthi kunamacala angu-XNUMX omdlavuza.
Indlela eyaziwa njenge- “Non-Negative Matrix Factorization” (i-NMF) isivumele ukuthi sisungule amaphrofayli amane okuvezwa kwezibulala-zinambuzane, akhombisa izinhlanganisela ezahlukahlukene zemithi yokubulala izinambuzane esichayeke kuzo ngokudla. Ngemuva kwalokho, amamodeli wezibalo asetshenzisiwe ukuhlaziya la maphrofayili nokuhlola ukuxhumana okungaba khona nengozi yokuba nomdlavuza webele.
Iphrofayili yeNMF n ° 1 ibonakala ngokuvezwa okuphezulu ezinhlotsheni ezi-4 zemithi yokubulala izinambuzane:
- umaphorase
- imazalil
- i-malathion
- thiabendazole
Kule phrofayili, abacwaningi baphawula ingozi eyengeziwe yomdlavuza webele we-postmenopausal abesifazane abakhuluphele ngokweqile (BMI phakathi kuka-25 no-30) noma obese (BMI> 30). Ngokuphambene nalokho, iphrofayili yeNMF No. 3 ibonakala ngokuvezwa okuphansi emithini yokubulala izinambuzane yokwenziwa kanye nokwehla okungama-43% engcupheni yomdlavuza webele we-postmenopausal. Amanye amaphrofayili amabili akhonjwe yi-NMF awazange ahlanganiswe nengozi yomdlavuza webele.
Yenzelani lezibulala-zinambuzane zokwenziwa?
Il umaphorase isetshenziswa, ngokwesibonelo, ezitshalweni ezisawolintshi, ukolweni, izithelo zamatshe noma isipinashi. L 'imazalil ibuye isetshenziselwe ukutshala izithelo ezisawolintshi, amazambane kanye nembewu. I- i-malathion, esetshenziswa ukulwa nezinambuzane ezincelisayo (ama-aphid, izinambuzane ezilinganayo), ivinjelwe eFrance kusukela ngo-2008 kodwa yagunyazwa kwamanye amazwe aseYurophu. I- thiabendazole isetshenziswa, phakathi kwezinye izinto, kummbila noma amazambane.
Izindlela ezingaphansi kwalezi zinhlangano zingaxhunyaniswa nezakhi ze-carcinogenic zeminye imithi yokubulala izinambuzane ye-organophosphate edala ukulimala kwe-DNA, ukwehliswa kwe-cell apoptosis, ukuguqulwa kwe-epigenetic, ukuphazanyiswa kwesiginali yeseli, ukubopha kuma-receptors enuzi noma ukufakwa kwengcindezi ye-oxidative.
Imiphumela yalolu cwaningo iphakamisa ukuxhumana phakathi kwamanye amaphrofayli okuvezwa kwezibulala-zinambuzane nokuqala komdlavuza webele we-postmenopausal. "Kepha ukuqinisekisa le datha - ochwepheshe baphetha - ngakolunye uhlangothi, kubalulekile ukwenza izifundo zokuhlola ukucacisa izindlela ezithintekayo futhi, ngakolunye uhlangothi, ukuqinisekisa le miphumela kwabanye abantu".
Imithombo Ijenali Yomhlaba Wonke ye Epidemiology / FAKA
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- Ama-pesticides: qagela ukuthi yiziphi izithelo nemifino okungcoliswe kakhulu? Izinga "elingamashumi amabili elingcolile"
- Izithelo nemifino: imikhiqizo eyi-12 ingcoliswe kakhulu yizibulala-zinambuzane (ezingamashumi amabili ezingcolile 2018)
- Amathiphu ama-5 okususa ama-pesticides ezithelweni nasemifino
