I-Omega-3s ibambezela ukuqhubekela phambili kwamanye amathumba amabi: ukutholakala, umsebenzi weqembu locwaningo lweInyuvesi yaseLeuven, iqinisekisa izifundo ezithile zomdlavuza zangaphambilini futhi ivule umnyango wezindlela ezintsha zokwelashwa.
Izici ezizuzisayo zalokho okuthiwa "ama-fatty acids amahle", abalulekile empilweni yomuntu futhi afunwa kakhulu yilabo abafuna ukudla okunempilo, abesevele esaziwa. Phakathi kwama-acid e-Omega-3 fatty, i-docosahexaenoic acid (DHA) ibalulekile ekusebenzeni kobuchopho, ukubona kanye nokulawulwa kwezimo zokuvuvukala.
Funda futhi: I-Omega 3: zonke izinzuzo zamafutha "amahle"
Ucwaningo lwangaphambilini luphinde lwabonisa iqhaza elingaba khona ekuvikeleni nasekunciphiseni ukuthuthuka kwezinhlobo ezithile zomdlavuza, kufaka phakathi ibele nekholoni.
Funda futhi: Omega 3 ukulwa nomdlavuza webele
Funda futhi: Umdlavuza wamakholoni: uwoyela wakudala wesibindi sokuwuvikela?
Ngo-2016, iqembu likaLeuven eliholwa ngu U-Olivier Feron, onguchwepheshe we-oncology, uthole ukuthi amangqamuzana omdlavuza asendaweni enesimo esincane esine-asidi angena esikhundleni sikashukela nge-lipids njengomthombo wamandla wokuwandisa. Ngo-2020, osebenza naye kamuva wakhombisa ukuthi lawa maseli afanayo anolaka kakhulu futhi athola amandla okushiya isimila sokuqala ukuze akhiqize ama-metastases.
Khonamanjalo, elinye iqembu laseyunivesithi efanayo, ngenkathi lisungula imithombo engcono yama-lipids okudla, lihlongoze ukuhlola ukusebenza kwamangqamuzana omdlavuza lapho kukhona ama-acid ahlukahlukene.
Ngakho-ke iqembu lathola masinyane ukuthi amangqamuzana omdlavuza we-acidotic aphendule ngezindlela eziphambene ngokuya nge-fatty acid abebemunca futhi, emasontweni ambalwa edlule, imiphumela ibimangalisa futhi imangaza.
Ngokushesha sathola ukuthi amanye ama-acid anamafutha avusa amangqamuzana omdlavuza ngenkathi amanye ewabulala
kuchaza abacwaningi.
Ikakhulu, i-DHA li ubuthi ngokoqobo. Lo shevu usebenza kumaseli omdlavuza ngesenzeko esibizwa i-ferroptosis, uhlobo lokufa kwamangqamuzana oluxhunyaniswe ne-peroxidation yamanye ama-acid anamafutha. Lapho inani elikhulu lamafutha acid angatheni esitokisini, iba nkulu ingozi yokuba namachibi awo.
© Inyuvesi yaseLeuven
Imvamisa, egumbini le-asidi ngaphakathi kwezicubu, amaseli agcina la mafutha acid kuma-lipid droplets, uhlobo lwenqwaba lapho okunamafutha acid kuvikelwe khona ku-oxidation. Kepha, lapho kukhona inani elikhulu le-DHA, iseli lomdlavuza ligcwele amandla futhi alikwazi ukugcina i-DHA, ehlanganisa futhi ifinyelele owesifazane ofileyo.
Kusetshenziswa i-lipid metabolism inhibitor evimbela ukwakheka kwe-lipid droplet, abacwaningi babone ukuthi le nto iyakhuliswa, eqinisekisa indlela ekhonjwe futhi ivule umnyango wamathuba. yokwelashwa okuhlangene.
Ekucwaningeni kwabo, abacwaningi basebenzise ikakhulukazi uhlelo lwe-3D tumor cell culture, ama-spheroids, amele imodeli yokuhlola ephakathi phakathi kwamasiko amaseli wendabuko kanye nezicubu e-vivo futhi, ezikhula nge-vitro, ezifinyeleleka ezinhlotsheni ezahlukahlukene zesilinganiso.
Ososayensi bakhombisile ukuthi, phambi kwe-DHA, ama-spheroids aqala akhula abese efakwa, eqinisekisa lokho ukukhula kwesisu kunciphise kakhulu ijubane.
© Inyuvesi yaseLeuven
Okwamanje umsebenzi waselebhu, oqinisekisa olunye ucwaningo olwedlule.
Nemiphumela "ebonakalayo"?
Okomuntu omdala - abacwaningi bayachaza - kunconywa kudle okungenani ama-250 mg we-DHA ngosuku. Kepha ucwaningo lukhombisa ukuthi ukudla kwethu kuhlinzeka ngama-50 kuya ku-100 mg ngosuku ngokwesilinganiso. Lokhu kungaphansi kakhulu kokudla okunconyiwe okuphansi.
Iqembu ngeke lime, lihlose i-DHA njengokhiye ku ezinye izindlela zokwelashwa komdlavuza, isebenza kangcono futhi mhlawumbe ingahlaseli kakhulu.
Umsebenzi ushicilelwe ngo- I-Cell Metabolism.
Imithombo yereferensi: Inyuvesi yaseLeuven / I-Cell Metabolism
Funda futhi:
