PPofuna kuthana ndi mliri woyambitsidwa ndi SARS-CoV-2 (kachilombo kamene kamayambitsa COVID-19), kodi zingakhale zothandiza kugwiritsa ntchito plasma ya anthu omwe adakumana ndikuthana kukumana kwapafupi ndi coronavirus yatsopano? Tidafunsa Giancarlo Liumbruno, director of the National Blood Center kuti awafotokozere.
Plasma: chida chothandizira kuthana ndi zoopsa?
La Chakudya ndi Mankhwala Osokoneza Bongo, bungwe lolamulira mankhwala ku United States, dzulo linalengeza cholinga chake kuthandizira kufikira kwa plasma kuchokera kuchira, ndiye kuti, otengedwa m'magazi a anthu omwe achira ku COVID-19, ndikuyembekeza kuti ma antibodies omwe alipo atha kuthandiza odwala ena ndikuchepetsa zovuta zoyambitsidwa ndi matendawa.
Kugwiritsa ntchito madzi otchedwa convalescent plasma kunali akukonzekera kale matenda ena opuma, monga SARS wa 2003, mliri wa fuluwenza wa H1N1 wa 2009 ndi MERS wa 2012. Komabe - alemba a FDA - ngakhale kulonjeza, plasma sanawonetsedwe kuti ndi othandiza pamatenda onse omwe amalingaliridwa. Za ichi Mayesero azachipatala amafunikira musanapereke kwa odwala onse a COVID-19.
Komabe, chifukwa chadzidzidzi yazaumoyo wa anthu onse, pomwe ntchito ya ofufuza ikupitilira, FDA imalola kugwiritsa ntchito, ngati mankhwala ofufuza, kuchiza odwala owopsa kapena owopsa.
Madzi a m'magazi ali ndi ma antibodies othandiza
Thupi lathu limapanga ma antibodies olimbana ndi matenda. «Kamodzi kuchiritsidwa, a plasma (yomwe imayimira gawo lamadzi lamagazi) muli ma antibodies: ndi ma immunoglobulins. Komabe, kugwiritsa ntchito plasma yoperekedwa ndi odwala ndi njira yothandizira osagwirizana ndi umboni wamphamvu wasayansi: imagwiritsidwa ntchito ngati mwachifundo pakagwa mwadzidzidzi»Kumveketsa. “Ndipo chifukwa chakuti ndi mankhwala oyamba, pamakhala kusowa kwa chidziwitso chotsimikizika cha sayansi chomwe chimatsimikizira kuti ndi chothandiza. Ndipo munthawi yomwe tikukumana nayo pano tikufunikirabe kumvetsetsa kuti ndi ma antibody angati omwe plasma idapatsira odwala omwe adalandira kachilomboka ali ndi ngati atasokoneza kachilomboka "
Mwachidule, idagwiritsidwa ntchito m'mbuyomu pakalibe mankhwala enieni komanso katemera.
Kodi "kugwiritsa ntchito achifundo" kumatanthauza chiyani
Munthawi imeneyi nthawi zambiri timamva za "kugwiritsa ntchito mankhwala achifundo". Plasma itha kugwiritsidwanso ntchito mwanjira imeneyi. Koma kodi izi zikutanthauza chiyani? Yofotokozedwa ndi Aifa (Italian Medicines Agency), "Kugwiritsa ntchito kotchedwa" kugwiritsa ntchito mwachifundo "(Lamulo la Unduna la 7 Seputembara 2017) likuyembekezeka kuti mankhwala akukumana ndi mayesero azachipatala, kunja kwa kuyesera komweko, Odwala omwe ali ndi matenda akulu kapena osowa kapena omwe ali pachiwopsezo cha moyo, pamene, malinga ndi dokotala, palibe njira zina zochiritsira zovomerezeka, kapena ngati wodwalayo sangaphatikizidwe pamayesero azachipatala kapena, pofuna kupitiliza chithandizo, kwa odwala omwe amathandizidwa kale ndi chithandizo chazachipatala woyeserera pang'ono gawo lachiwiri lachipatala ". Ndiponso: "Potengera malamulo apano, ndizotheka kugwiritsa ntchito mankhwala a matenda osowa ndi zotupa zosowa zomwe zotsatira zokha za kafukufuku woyeserera wa gawo I zimapezeka zomwe zalemba zochitika zawo ndi chitetezo; Zikatero, pempholi liyenera kutengera phindu lomwe lingawonekere potengera momwe amagwirira ntchito komanso mphamvu ya mankhwala ".
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Plasma ndi chinthu chofunikira kwambiri
"Tiyeni tiganizire za kafumbata," akutero a Liumbruno. «Katemerayu amateteza chitetezo cha mthupi komanso kupanga ma antibodies omwe, pakapita nthawi, amateteza chitetezo chokhazikika». Pulogalamu ya katemerachoncho, sichimateteza nthawi yomweyo, koma amalimbikitsa chitetezo cha mthupi kutulutsa ma antibodies kuti athetse "mdani": mumalandira katemera kuti musadwale.
«Kumbali inayi, kuchipatala sitigwiritsa ntchito plasma koma ku kasamalidwe ka tetanus immunoglobulins ochokera ku plasma. Mwanjira ina, Therapy si anachita kudzera kulowetsedwa plasma, yomwe imakhala ndi ma antibodies komanso zinthu zina, koma popereka ma antibodies enieni omwe amatengedwa ndi njira zamagawo ».
Mankhwala opulumutsa moyo amachokera ku plasma
Pomaliza, madzi am`magazi ndi chida chamtengo wapatali chomwe chimagwiritsidwa ntchito ngati zopangira kutulutsa mankhwala opulumutsa moyo, monga mankhwala otchedwa opangidwa ndi plasma, kuphatikizapo ma immunoglobulins.
Komabe, kulimbana ndi kachilombo ka SARS-CoV-2 - popeza tilibe katemera wothandiza kupewa kufalikira kwa kachilomboka, kapena mankhwala enieni ochiritsira COVID 19 - pampikisano wothana ndi nthawi yomwe tikufuna kuyesanso njirayi. pa kasamalidwe ka odwala kwambiri. "Koma ndikubwereza - ndikutsindika Liumbruno - ndi njira yadzidzidzi yothandizira ".
Chilichonse chiri chokonzeka ku Policlinico di Pavia
Pakadali pano San Matteo Polyclinic ku Pavia apanga njira yothandizira ya amachiza odwala odwala kwambiri pomupatsa magazi a plasma: «Ndondomekoyi idavomerezedwa ndi komiti yoona zamakhalidwe achipatala yomwe, kuchokera ku National Blood Center, idalandira njira yosankhira odwala omwe akupereka» akumaliza Liumbruno.
Malinga ndi Superior Health Council, wodwalayo yemwe sawonetsanso zizindikiro za matenda a Covid-19 komanso yemwe ali ndi vuto m'mayeso awiri motsatizana, omwe adachitidwa patadutsa maola 24, kufunafuna coronavirus yatsopano, amadziwika kuti wachiritsidwa.
Ndikudikirira kuti ndikhoze kupitilira ndikulowetsedwa, Cesare Perotti, wamkulu wa Immunohematology ndi ntchito yochotsa anthu magazi ku Policlinico di Pavia, akuti: "ndichithandizo chachilengedwe komanso chotsika mtengo chomwe, potengera vuto ladzidzidzi, atha kuthandiza kwambiri".
"Ndondomeko yathu ndiyotseguka, olembetsedwa ku registry ya ClinicalTrial.gov: aAmerican Society of Hematology adatifunsa kuti tigawane izi kuti tithane ndi vutoli ».
"Zachidziwikire - akupitilizabe - tikudziwabe zochepa za kachilomboka, koma kulowetsedwa m'magazi ndi njira yomwe idagwiritsidwapo ntchito m'mbuyomu, mwachitsanzo kwa hepatitis B pomwe kunalibe katemera, wokhala ndi Ebola ... komanso ku China adalandiridwa zotsatira pogwiritsa ntchito plasma kuchokera kwa odwala atachiritsidwa ku matenda ».
“Talandira chilolezo kuchokera ku National Blood Center kuti titenge plasma ndi mankhwala oyenera a wodwalayo kuchokera kwa odwala obala. Tikuyembekezera kuti titha kupitiliza ndi infusions ».
L'articolo Coronavirus, mankhwala ndi mankhwala: chifukwa chomwe plasma ya odwala omwe adachira ndiyofunika zikuwoneka kuti ndizoyamba Mkazi.
