Kwenguva yekutanga, masayendisiti anobatanidza kunwa kwakanyanya kweyakagadziriswa uye isina kugadziriswa nyama tsvuku ine kukuvara kweDNA mune varwere vane kenza yakajeka.
Kudya nyama kunokanganisa hutano hwedu sei? Dzimwe nyanzvi dzakabatanidza genetic mutation inoratidza kukuvara kweDNA kune yakatsvuka nyama yekudyiwa uye nekuwedzera kufa-zvine hukama nekenza mune colorectal cancer (CRC) varwere. Izvo zvakawanikwa, sekureva kwemasayendisiti, zvinogona kutungamira mukuvandudzwa kweatsva kuongororwa kana CRC njodzi biomarkers uye kuratidza mikana yekurapa.
Ndinodzidza, rakabudiswa muCancer Discovery, iyo yesainzi magazini yeAmerican Association for Cancer Research, uye inotungamirwa naMarios Giannakis, purofesa wezvekurapa paHarvard Medical School uye oncologist kuDana-Farber Cancer Institute, nekudaro inopa mufananidzo wakawedzera kana kushoma pane zvakatotsigirwa kwenguva yakati nezvakawanda zvehutachiona zvidzidzo.
Izvi zvakawanikwa zvinoratidza kuti kunwiwa kwenyama tsvuku zvinogona kukonzera kukuvara kunotungamira kune cancer cancer mutations muKRAS uye PIK3CA, nekudaro kukurudzira kukura kwekenza yakajeka. Yedu data inowedzera kutsigira nyama tsvuku kudya senge njodzi yekugomarara kwecolorectal uye zvakare inopa mikana yekudzivirira, kuona uye kurapa chirwere ichi, anodaro Giannakis.
Takamboziva kwechinguva kuti kunwa nyama yakashandurwa uye nyama tsvuku chinhu chinokonzeresa kugomarara, ”akadaro. Sangano reInternational Agency for Research on Cancer rakati muna 2015 nyama yakashandurwa yaive carcinogenic uye kuti nyama tsvuku ingangoita carcinogenic kuvanhu. Kwayedza mumatanho epamberi yakaratidza kuti nyama tsvuku inodyiwa inogona kusimudzira kuumbwa kwemakemikari makemikari mukoloni, asi yakanangana nemaMorekisheni pamwe nekuvandudzwa kwekenza yakajeka muvarwere haina kuratidzwa. Sokutaura kwakaita Giannakis, “Chiri kushaikwa humbowo hwekuti kenza dzevarwere dzakachenuruka dzine maitiro chaiwo ekuchinja-chinja anogona kukonzerwa nenyama tsvuku. Kuziva shanduko idzi mumakemikari maseru anokonzeresa kuti gomarara haringotsigire basa retsvuku nyama mukugadzira gomarara, asi zvakare rinopa nzira nyowani dzekudzivirira gomarara nekurapwa. '
Kudzidza
Kuti vaone shanduko yemajini inosanganisirwa nenyama tsvuku, vatsvaguriri vakaita kuteedzana kwemaviri pamatanho epamuviri asina kurapwa maronda kubva kuvarwere mazana mapfumbamwe eCRC vakapinda muzvidzidzo zvitatu zvinotarisirwa (zveVanamukoti 'Hutano Zvidzidzo I uye II - NHS - uye zvinotevera- kumusoro kudzidza kwevashandi vehutano - HPFS). Murwere wega wega akange ambopa ruzivo nezve dhayeti yavo, mararamiro avo nezvimwe zvinhu mukati memakore akati wandei vasati vaonekwa kuti vane chirwere checancer, uye kuti vaone kana zvikamu zvekudya zvakakonzera siginicha yekunamatira muCRC, ivo vakashandisa zviyero zvakadzokororwa zvakaunganidzwa. yenyama, yehuku uye yekudyiwa kwehove mumagiramu pazuva muNHS uye HPFS cohorts.
Kuongororwa kwechikwata cheDNA kuteedzerana data kwakaratidza kuvapo kwemasaini akati wandei mune echinyakare uye ane cancer cancer colon, kusanganisira siginecha inoratidza "alkylation". chimiro cheDNA kukuvara. Iyo siginecha yekunamatira yaibatanidzwa zvakanyanya nekufungidzira kwekudyiwa kwenyama tsvuku yakashandurwa kana isina kugadziriswa, asi kwete neyakafungidzirwa yekudyiwa kwehuku kana hove, kana nezvimwe zvinorarama.
Uye zvakasiyana nemhedzisiro yekutsvuka kwenyama yekudyiwa, zvimwe zvinodyiwa zvekudya (hove uye kudya kwehuku) uye mararamiro ehupenyu, kusanganisira muviri mass index, kunwa doro, kuputa, uye kuita zvemuviri, hazvina kuratidza chero hukama hwakakosha neiyo alkylating siginecha.
Vachishandisa muenzaniso wekufanofungidzira, ivo vaongorori vakaona magen'a eKRAS nePIK3CA sezvingangoita zvinangwa zvekushandurwa kunoitwa alkylation. Zvinopindirana nekufungidzira uku, vakaona kuti macancer akaomarara akachengeta KRAS G12D, KRAS G13D, kana PIK3CA E545K mutyairi shanduko, ayo anowanzoonekwa mukenza yakajeka.
Iyo ongororo inoratidza kuti kukuvara kweDNA kunogona kukanganisa iyo KRAS geni, kunyanya kune mbiri shanduko (G12D e G13D) uye geni PIK3CA, zvese zviri zviviri zvakabatana nekenza yakajeka. Asi sekureva kwaGiannakis, iyo concatenation yezviitiko zvinokonzeresa zviitiko ichiri yakareba:
Isu takatarisa nehukama pakati penyama tsvuku uye alkylation mutation. Ipapo tinoziva kuti shanduko idzi dzinokanganisa geni reKRAS uye kuti shanduko yeKRAS inogona kukonzera cancer.
Zvinoreva kuti mamwe magene anowanikwa anogona kutungamira mukuwedzera kana kudzikiswa muhuwandu hwekukuvara kunounganidzwa nevanhu vakasiyana paiyo yakafanana nyama tsvuku yakadyiwa. Izvi zvinoda kumwe kutsvagurudza kuti unzwisise biology iri shure kwekuvandudzwa kwemamota. Asi chimwe chokwadi chinoita kunge chinogara chiripo: nyama tsvuku inoramba iri njodzi yekukonzeresa kenza uye mamwe marudzi ekenza.
Kunobva: Kenza Discovery
Verenga zvakare:
- Kudya nyama kunowedzera njodzi yechirwere chemwoyo, chirwere cheshuga, uye zvimwe zvisina gomarara
- Nyanzvi dzinopa yambiro inotyisa, inguva yekucheka nyama tsvuku
- Kwete chete nyama tsvuku: huku inogona zvakare kukonzera chirwere chemoyo. Chidzidzo chitsva
- Nyama chena yakashata senyama tsvuku maererano necholesterol
- Kwete kenza chete. Nyama tsvuku inowedzera njodzi yemarudzi mapfumbamwe ezvirwere
