Kuti mankhwala ophera tizilombo amayambitsa zotupa tsopano zikuwoneka kuti zakhazikitsidwa. Osati kokha glyphosate yamtundu uliwonse imalumikizidwa ndi kuyamba kwa khansa, kapena wotsimikiza mankhwala ophera tizilombo ku chiopsezo chowonjezeka cha khansa yaubwana a dongosolo lamanjenje lamkati, tsopano zikuwonekeratu kuti ngakhale kukhudzana ndi chakudya cha mankhwala ena ophera tizilombo kumatha kuyambitsa khansa ya m'mawere atatha msambo.
Izi ndi zomwe zimatuluka m'modzi situdiyo French motsogozedwa ndi gulu la ofufuza ochokera ku CNAM, INSERM ndi INRAE ndikufalitsa muInternational Journal of Epidemiology, akuwunika mgwirizano womwe ulipo pakati pa zakudya zakumwa mankhwala ophera tizilombo komanso chiwopsezo chokhala ndi khansa ya m'mawere mwa amayi omwe atha msambo omwe ali mgulu la projekiti ya NutriNet-Santé.
Kafukufukuyu adakhudza azimayi 13.149 omwe amapezeka pambuyo popanga msinkhu, kuphatikiza 169 za khansa. Ofufuzawo anayeza kupezeka kwa zinthu 25 zogwira ntchito popanga mankhwala ovomerezeka mu Europe, kuyambira ndi omwe amagwiritsidwa ntchito muulimi wa organic.
M'malo mwake, malinga ndi kafukufukuyu, akuti mankhwala ena ophera tizilombo omwe amagwiritsidwa ntchito ku Europe ali ndi zotsatirapo zovulaza thanzi la munthu: zimayambitsa zovuta zam'madzi komanso zimakhala ndi khansa. Chiyanjano pakati pa kupezeka kwa mankhwala ophera tizilombo kudzera mu chakudya ndi khansa ya m'mawere mwa anthu ambiri sichiphunziridwa bwino. Ofufuza anali atawonetsa kale kuti ogula zakudya zopangidwa mwachilengedwe mgulu la NutriNet-Santé anali ndi chiopsezo chochepa cha khansa ya postmenopausal. Gulu lomweli limapitiliza ntchito yawo, nthawi ino kuyang'ana kwambiri ma cocktails ophera tizilombo m'gulu lino.
Phunziro
Kafukufuku watsopano wazaka zinayi adayamba mu 2014. Ophunzira adamaliza kufunsa mafunso kuti adziwe zakumwa zachilengedwe komanso zakudya wamba. Amayi okwana 13.149 omwe atha msinkhu wopita kumwezi ataphatikizidwa ndikuwunika ndipo milandu ya khansa ya 169 idanenedwa.
Njira yotchedwa "Non-Negative Matrix Factorization" (NMF) yatilola kukhazikitsa ma profiles anayi ophera tizilombo, omwe akuwonetsa zosakaniza zosiyanasiyana za mankhwala omwe timakumana nawo kudzera pachakudya. Kenako, mitundu yamawerengero idagwiritsidwa ntchito kupenda ma profiles awa ndikuwona kulumikizana komwe kungakhalepo ndi chiwopsezo chokhala ndi khansa ya m'mawere.
Mbiri ya NMF n ° 1 imadziwika ndi mitundu 4 ya mankhwala ophera tizilombo:
- alireza
- imazal
- malathion
- thiabendazole
Mu mbiriyi, ofufuzawo akuti ali ndi chiopsezo chowonjezeka cha khansa ya m'mawere yomwe imatha kutha msinkhu akazi onenepa kwambiri (BMI pakati pa 25 ndi 30) kapena ochepa kwambiri (BMI> 30). Mosiyana ndi izi, mbiri ya NMF No. 3 imadziwika ndi kuchepa kwambiri kwa mankhwala ophera tizilombo komanso kutsika kwa 43% pangozi ya khansa ya m'mawere yotuluka m'mimba. Mbiri zina ziwiri zodziwika ndi NMF sizinakhudzidwe ndi chiopsezo cha khansa ya m'mawere.
Kodi mankhwala ophera tizilombo amenewa ndi ati?
Il alireza imagwiritsidwa ntchito, mwachitsanzo, zipatso za citrus, tirigu, zipatso zamwala kapena sipinachi. L 'imazal imagwiritsidwanso ntchito kulima zipatso za zipatso, mbatata ndi mbewu. Pulogalamu ya malathion, yomwe idagwiritsidwa ntchito polimbana ndi tizilombo toyamwa (nsabwe za m'masamba, tizilombo tating'onoting'ono), yaletsedwa ku France kuyambira 2008 koma idaloledwa m'maiko ena aku Europe. Pulogalamu ya thiabendazole imagwiritsidwa ntchito, mwa zina, pa chimanga kapena mbatata.
Njira zomwe zimayendera mabungwewa zitha kulumikizidwa ndi ziwombankhanga za mankhwala ophera tizilombo a organophosphate omwe amawononga DNA, kuchotsedwa kwa cell apoptosis, kusintha kwa epigenetic, kusokonekera kwa ma cell, kumangiriza ma receptors a nyukiliya kapena kupsinjika kwa kupsinjika kwa oxidative.
Zotsatira za kafukufukuyu zikusonyeza kulumikizana pakati pa mbiri yakudziwitsa za mankhwala ophera tizilombo komanso kuyambika kwa khansa ya m'mawere yomwe imatha kutha msinkhu. "Koma kutsimikizira izi - akatswiri akumaliza - mbali ina, ndikofunikira kuchita maphunziro oyeserera kuti afotokozere bwino zomwe zimachitika ndipo, kumbali inayo, kutsimikizira zotsatirazi kwa anthu ena".
Malire: International Journal of Epidemiology / KUPATSA
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