Khansa ya m'matumbo: idawulula koyamba momwe nyama yofiira yochulukirapo imasinthira DNA, ndikupanga maselo a khansa

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Kwa nthawi yoyamba, asayansi amagwirizanitsa kumwa kwambiri nyama yofiira yosakonzedwa komanso yosasinthidwa ndi kuwonongeka kwa DNA kwa odwala khansa yoyipa

Kodi kudya nyama kumakhudza bwanji thanzi lathu? Akatswiri ena adalumikiza kusinthika kwa majini komwe kumawonetsa kuwonongeka kwa DNA pakudya nyama kofiira kwambiri komanso kufa kwa anthu omwe ali ndi khansa m'matenda a khansa ya m'mimba (CRC). Zomwe apezazi, malinga ndi asayansi, zitha kupangitsa kuti pakhale njira zatsopano zowunikira matenda a CRC ndikuwonetsa mwayi wothandizira.

Ndikuphunzira, lofalitsidwa mu Cancer Discovery, magazini yasayansi ya American Association for Cancer Research, ndipo motsogozedwa ndi Marios Giannakis, pulofesa wa zamankhwala ku Harvard Medical School komanso oncologist ku Dana-Farber Cancer Institute, motero amapereka chithunzi chochepa kwambiri cha zomwe zathandizidwa kale kwakanthawi ndimaphunziro ambiri a miliri.

Zotsatira izi zikuwonetsa kuti kumwa nyama yofiira Zingayambitse kuwonongeka komwe kumabweretsa kusintha kwa khansa mu KRAS ndi PIK3CA, potero kulimbikitsa kukula kwa khansa yoyipa. Deta yathu imathandizanso kudya nyama yofiira monga chiopsezo cha khansa yamphongo komanso imapatsanso mwayi woteteza, kuzindikira ndi kuchiza matendawa, akutero Giannakis.

Takhala tikudziwa kwakanthawi kuti kudya nyama yophika komanso nyama yofiira ndi chiopsezo cha khansa yoyipa, "adalongosola. Bungwe la International Agency for Research on Cancer linati mu 2015 kuti nyama yothira mafuta imayambitsa khansa komanso kuti nyama yofiira ndiyomwe imayambitsa khansa kwa anthu. Kuyesa kwamitundu yoyeserera kunanenanso kuti kudya nyama yofiira kumatha kulimbikitsa mapangidwe am'magazi a khansa m'matumbo, koma kulumikizana molunjika ndi kukula kwa khansa yoyipa ya odwala sikunawonetsedwe. Monga momwe Giannakis ananenera, “Chomwe chikusoweka ndi umboni woti khansa yamitundumitundu ya odwala imakhala ndi kusintha komwe kumachitika chifukwa cha nyama yofiira. Kuzindikira kusintha kwamaselo m'maselo am'matumbo omwe angayambitse khansa sikungogwirizira gawo la nyama yofiira pakukula kwa khansa yoyipa, komanso kungapatsenso njira zatsopano zopewera khansa ndi chithandizo. '

Phunziro 

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Pozindikira kusintha kwa majini komwe kumakhudzana ndi kudya nyama yofiira, ofufuzawo adachita mayendedwe onse atafanana ndi zotupa zomwe sizinachitike kuchokera kwa odwala 900 CRC omwe adachita nawo maphunziro atatu (Nurses 'Health Study I ndi II - NHS - ndi zotsatirazi- maphunziro a akatswiri azaumoyo - HPFS). Wodwala aliyense anali atapereka kale chidziwitso pazakudya zawo, moyo wawo komanso zinthu zina pazaka zingapo asanawonekere kuti ali ndi khansa yoyipa, ndikuwunika ngati magawo azakudya adathandizira siginecha ya CRC, adagwiritsa ntchito miyezo mobwerezabwereza yomwe amapeza nyama, nkhuku ndi nsomba mumagalamu patsiku m'magulu a NHS ndi HPFS.

Kuwunika kwa gululi pamasamba omwe adafufuza za DNA kudawulula kupezeka kwa ma signature angapo osinthira munyama zachilendo komanso za khansa, kuphatikiza siginecha ya "alkylation". mawonekedwe a kuwonongeka kwa DNA. Siginecha ya alkylating idalumikizidwa kwambiri ndikudya koyambirira kwa nyama yofiira yosinthidwa kapena yosakonzedwa, koma osati ndi nkhuku kapena nsomba zomwe zidapezeka kale, kapena ndizinthu zina zamoyo. 

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Ndipo mosiyana ndi zotsatira zakudya nyama yofiira, mitundu ina yazakudya (nsomba ndi kudya nkhuku) ndi momwe zimakhalira, kuphatikiza kuchuluka kwa thupi, kumwa mowa, kusuta, komanso kuchita masewera olimbitsa thupi, sizinawonetse mgwirizano uliwonse ndi siginecha yolumikizira.


Pogwiritsa ntchito njira yolosera, ofufuzawo adazindikira kuti majini a KRAS ndi PIK3CA ndi omwe angakhale chandamale pakusintha kwa alkylation. Mogwirizana ndi kuneneraku, adapeza kuti khansa yoyera yomwe imakhala ndi KRAS G12D, KRAS G13D, kapena PIK3CA E545K zosintha zoyendetsa, zomwe zimakonda kuwonedwa mu khansa yoyipa, zidapangitsa kuti siginecha yolumikizana ikhale yopindulitsa kuposa zotupa popanda izi.

Kuwunikaku kukuwonetsa kuti kuwonongeka kwa DNA kumatha kukhudza mtundu wa KRAS, makamaka pazosintha ziwiri (G12D G13D) ndi jini Chithunzi cha PIK3CA, Zonsezi zimagwirizanitsidwa kale ndi khansa yoyipa. Koma malinga ndi Giannakis, kuphatikiza kwa zomwe zingachitike pazovuta akadali kwanthawi yayitali:

Tawona kuyanjana pakati pa nyama yofiira ndi kusintha kwa alkylation. Kenako timadziwa kuti kusinthaku kumakhudza mtundu wa KRAS ndikuti kusintha kwa KRAS kumatha kuyambitsa khansa.

Zomwe zikutanthauza kuti zina zowonjezera zamtundu zimatha kupezeka zomwe zitha kubweretsa kuwonjezeka kapena kuchepa kwa kuwonongeka komwe anthu osiyanasiyana amadzipezera nyama yofiira yomweyo. Izi zidzafunika kuti mufufuze kwambiri kuti mumvetsetse biology yomwe imayambitsa zotupa. Koma chowonadi chimodzi chikuwoneka ngati chosasintha: nyama yofiira imakhalabe pachiwopsezo cha khansa yoyipa ndi mitundu ina ya khansa.

Chitsime: Kupeza Khansa

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